Cross-Reactivity, Epitope Spreading, and De Novo Immune Stimulation Are Possible Mechanisms of Cross-Protection of Nonvaccine Human Papillomavirus (HPV) Types in Recipients of HPV Therapeutic Vaccines
Identifieur interne : 000056 ( Main/Exploration ); précédent : 000055; suivant : 000057Cross-Reactivity, Epitope Spreading, and De Novo Immune Stimulation Are Possible Mechanisms of Cross-Protection of Nonvaccine Human Papillomavirus (HPV) Types in Recipients of HPV Therapeutic Vaccines
Auteurs : Mayumi Nakagawa [États-Unis] ; William Greenfield [États-Unis] ; Andrea Moerman-Herzog [États-Unis] ; Hannah N. Coleman [États-Unis]Source :
- Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2015.
Abstract
Numerous versions of human papillomavirus (HPV) therapeutic vaccines designed to treat individuals with established HPV infection, including those with cervical intraepithelial neoplasia (CIN), are in development because approved prophylactic vaccines are not effective once HPV infection is established. As human papillomavirus 16 (HPV-16) is the most commonly detected type worldwide, all versions of HPV therapeutic vaccines contain HPV-16, and some also contain HPV-18. While these two HPV types are responsible for approximately 70% of cervical cancer cases, there are other high-risk HPV types known to cause malignancy. Therefore, it would be of interest to assess whether these HPV therapeutic vaccines may confer cross-protection against other high-risk HPV types. Data available from a few clinical trials that enrolled subjects with CINs regardless of the HPV type(s) present demonstrated clinical responses, as measured by CIN regression, in subjects with both vaccine-matched and nonvaccine HPV types. The currently available evidence demonstrating cross-reactivity, epitope spreading, and
Url:
DOI: 10.1128/CVI.00149-15
PubMed: 25947147
PubMed Central: 4478515
Affiliations:
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Coleman</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas</wicri:regionArea><placeName><region type="state">Arkansas</region></placeName></affiliation></author></analytic><series><title level="j">Clinical and Vaccine Immunology : CVI</title><idno type="ISSN">1556-6811</idno><idno type="eISSN">1556-679X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Numerous versions of human papillomavirus (HPV) therapeutic vaccines designed to treat individuals with established HPV infection, including those with cervical intraepithelial neoplasia (CIN), are in development because approved prophylactic vaccines are not effective once HPV infection is established. 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The currently available evidence demonstrating cross-reactivity, epitope spreading, and <italic>de novo</italic> immune stimulation as possible mechanisms of cross-protection conferred by investigational HPV therapeutic vaccines is discussed.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Arkansas</li></region></list><tree><country name="États-Unis"><region name="Arkansas"><name sortKey="Nakagawa, Mayumi" sort="Nakagawa, Mayumi" uniqKey="Nakagawa M" first="Mayumi" last="Nakagawa">Mayumi Nakagawa</name></region><name sortKey="Coleman, Hannah N" sort="Coleman, Hannah N" uniqKey="Coleman H" first="Hannah N." last="Coleman">Hannah N. Coleman</name><name sortKey="Greenfield, William" sort="Greenfield, William" uniqKey="Greenfield W" first="William" last="Greenfield">William Greenfield</name><name sortKey="Moerman Herzog, Andrea" sort="Moerman Herzog, Andrea" uniqKey="Moerman Herzog A" first="Andrea" last="Moerman-Herzog">Andrea Moerman-Herzog</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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